Tetanus Toxin C-Fragment: The Courier and the Cure?
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چکیده
منابع مشابه
Tetanus Toxin C-Fragment: The Courier and the Cure?
In many neurological disorders strategies for a specific delivery of a biological activity from the periphery to the central nervous system (CNS) remains a considerable challenge for successful therapy. Reporter assays have established that the non-toxic C-fragment of tetanus toxin (TTC), provided either as protein or encoded by non-viral naked DNA plasmid, binds pre-synaptic motor neuron termi...
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Tetanus is a disease caused by tetanus toxin, a potent inhibitor for the release of inhibitory neurotransmitter in the central nervous system that causes spastic paralysis. Fragment C (52 kD) of this toxin is responsible for binding to the neuronal membrane. For this reason, and also its non toxigenic and immunogenic nature, this fragment might be ideal for new vaccine development. Presently, w...
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Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B. anthracis strain was constructed by integrating into the chromosome a translational fusion harboring the DNA fragments encoding the cell wall-targeting domain of the S-layer protein EA1 and tetanus...
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The non-toxic C fragment of tetanus toxin fused to the beta-galactosidase enzyme was analysed as a neuroanatomical tracer. After intramuscular injection in rat tongue, its location in the hypoglossal network was compared with other classic tracers such as neurotropic viruses. The hybrid protein reached second and higher-order neurons after crossing several synapses. It appears to be a powerful ...
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ژورنال
عنوان ژورنال: Toxins
سال: 2010
ISSN: 2072-6651
DOI: 10.3390/toxins2112622